ENO2 and HK1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ENO2	HK1
Description		enolase 2	hexokinase 1
Image
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Membrane Perikaryon Extracellular Exosome	Cell Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft
	Molecular Function	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Identical Protein Binding Peptidoglycan Binding
	Biological Process	Gluconeogenesis Glycolytic Process Canonical Glycolysis	Cellular Glucose Homeostasis Positive Regulation Of Cytokine Secretion Involved In Immune Response Fructose 6-phosphate Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response Innate Immune Response Carbohydrate Phosphorylation Positive Regulation Of Interleukin-1 Beta Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion
Pathways		Glycolysis Gluconeogenesis	Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs		2-Phosphoglycolic Acid	alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS			Birth weight ( 31043758) Glycated hemoglobin levels ( 20858683 31213470 19096518 28898252) Glycemic traits (pregnancy) ( 23903356) Hematocrit ( 27863252 19862010) Hemoglobin ( 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Ischemic stroke (cardioembolic) ( 29531354) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 20139978 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		25 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C	6 interacting genes: APP ENO2 SCMH1 USP54 VDAC1 VDAC2
Entrez ID		2026	3098
HPRD ID		00573	00809
Ensembl ID		ENSG00000111674	ENSG00000156515
Uniprot IDs		P09104 Q6FHV6	A0A024QZK7 A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs		1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?
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