HK1 and SCMH1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		HK1	SCMH1
Description		hexokinase 1	Scm polycomb group protein homolog 1
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GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft	Nucleoplasm Chromocenter
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Identical Protein Binding Peptidoglycan Binding	Protein Binding
	Biological Process	Cellular Glucose Homeostasis Positive Regulation Of Cytokine Secretion Involved In Immune Response Fructose 6-phosphate Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response Innate Immune Response Carbohydrate Phosphorylation Positive Regulation Of Interleukin-1 Beta Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated
Pathways		Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs		alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine	Beta-Mercaptoethanol
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Birth weight ( 31043758) Glycated hemoglobin levels ( 20858683 31213470 19096518 28898252) Glycemic traits (pregnancy) ( 23903356) Hematocrit ( 27863252 19862010) Hemoglobin ( 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Ischemic stroke (cardioembolic) ( 29531354) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 20139978 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435)
Interacting Genes		6 interacting genes: APP ENO2 SCMH1 USP54 VDAC1 VDAC2	16 interacting genes: EWSR1 GMNN HK1 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M TMEM11 TOB1 UBQLN1 UBQLN4
Entrez ID		3098	22955
HPRD ID		00809	11540
Ensembl ID		ENSG00000156515	ENSG00000010803
Uniprot IDs		A0A024QZK7 A8K7J7 B3KXY9 P19367 P78542 Q59FD4	B3KMZ7 Q96GD3
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	2P0K
Enriched GO Terms of Interacting Partners?
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