HK1 and VDAC2

Number of citations of the paper that reports this interaction (PubMedID 8420959)
41

Data Source:
HPRD (in vitro)

		HK1	VDAC2
Description		hexokinase 1	voltage dependent anion channel 2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Synaptic Vesicle Mitochondrial Nucleoid Pore Complex
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Identical Protein Binding Peptidoglycan Binding	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity
	Biological Process	Cellular Glucose Homeostasis Positive Regulation Of Cytokine Secretion Involved In Immune Response Fructose 6-phosphate Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response Innate Immune Response Carbohydrate Phosphorylation Positive Regulation Of Interleukin-1 Beta Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion	Anion Transport Binding Of Sperm To Zona Pellucida Inorganic Anion Transport Negative Regulation Of Protein Polymerization Anion Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis	Ub-specific processing proteases Mitochondrial calcium ion transport
Drugs		alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine	Aluminium monostearate PRLX 93936
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Birth weight ( 31043758) Glycated hemoglobin levels ( 20858683 31213470 19096518 28898252) Glycemic traits (pregnancy) ( 23903356) Hematocrit ( 27863252 19862010) Hemoglobin ( 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Ischemic stroke (cardioembolic) ( 29531354) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 20139978 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		6 interacting genes: APP ENO2 SCMH1 USP54 VDAC1 VDAC2	8 interacting genes: ADRB2 APP BAK1 CYCS ECT2 HK1 NEDD4L RPS3A
Entrez ID		3098	7417
HPRD ID		00809	01904
Ensembl ID		ENSG00000156515	ENSG00000165637
Uniprot IDs		A0A024QZK7 A8K7J7 B3KXY9 P19367 P78542 Q59FD4	A0A024QZT0 B4DKM5 P45880
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?
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