EIF5 and PUM1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		EIF5	PUM1
Description		eukaryotic translation initiation factor 5	pumilio RNA binding family member 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	RNA Binding Translation Initiation Factor Activity GTPase Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Activation Of GTPase Activity	Spermatogenesis Adult Locomotory Behavior Posttranscriptional Regulation Of Gene Expression Posttranscriptional Gene Silencing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of Gene Silencing By MiRNA MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		15 interacting genes: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1	4 interacting genes: ATXN1 EIF5 PRR12 SMAD1
Entrez ID		1983	9698
HPRD ID		03417	06230
Ensembl ID		ENSG00000100664	ENSG00000134644
Uniprot IDs		A0A024R6Q1 P55010	Q14671
PDB IDs		2E9H 2G2K 2IU1	1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?
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