EIF5 and EIF1AX

Number of citations of the paper that reports this interaction (PubMedID 10982835)
35

Data Source:
HPRD (in vitro, in vivo)

		EIF5	EIF1AX
Description		eukaryotic translation initiation factor 5	eukaryotic translation initiation factor 1A X-linked
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Cytosol
	Molecular Function	RNA Binding Translation Initiation Factor Activity GTPase Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Activation Of GTPase Activity	Translational Initiation
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		15 interacting genes: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1	8 interacting genes: APP EIF2S1 EIF3C EIF5 EIF5B HSPB1 IKBKG IPO13
Entrez ID		1983	1964
HPRD ID		03417	02174
Ensembl ID		ENSG00000100664	ENSG00000173674
Uniprot IDs		A0A024R6Q1 P55010	P47813
PDB IDs		2E9H 2G2K 2IU1	1D7Q 3ZJY 4KZY 4KZZ
Enriched GO Terms of Interacting Partners?
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