EIF2S3 and NDRG1

Number of citations of the paper that reports this interaction (PubMedID 17220478)
24

Data Source:
HPRD (in vivo)

		EIF2S3	NDRG1
Description		eukaryotic translation initiation factor 2 subunit gamma	N-myc downstream regulated 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Positive Regulation Of Translational Fidelity Transmembrane Transport	Signal Transduction Negative Regulation Of Cell Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Regulation Of Apoptotic Process Mast Cell Activation Cellular Response To Hypoxia Postsynapse Organization
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Prostate-specific antigen levels ( 28139693)	Estimated glomerular filtration rate ( 31015462) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		2 interacting genes: METAP2 NDRG1	71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN GPAA1 GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		1968	10397
HPRD ID		02155	05586
Ensembl ID		ENSG00000130741	ENSG00000104419
Uniprot IDs		P41091	B3KWB2 Q8N959 Q92597
PDB IDs		6FEC 6K71 6K72 6O81 6O85
Enriched GO Terms of Interacting Partners?
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