EIF2S3

Description		eukaryotic translation initiation factor 2 subunit gamma
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Extracellular Exosome
	Molecular Function	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translational Initiation Positive Regulation Of Translational Fidelity Transmembrane Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Prostate-specific antigen levels ( 28139693)
Interacting Genes		2 interacting genes: METAP2 NDRG1
Entrez ID		1968
HPRD ID		02155
Ensembl ID		ENSG00000130741
Uniprot IDs		P41091
PDB IDs		6FEC 6K71 6K72 6O81 6O85
Enriched GO Terms of Interacting Partners?
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