NR0B1 and RORA

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		NR0B1	RORA
Description		nuclear receptor subfamily 0 group B member 1	RAR related orphan receptor A
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck Centriolar Satellite Polysomal Ribosome Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity RNA Binding Nuclear Receptor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding DNA Hairpin Binding Steroid Hormone Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Steroid Biosynthetic Process Spermatogenesis Protein Localization Gonad Development Male Gonad Development Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Steroid Hormone Mediated Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Sertoli Cell Differentiation	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Cholesterol Homeostasis Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia T-helper 17 Cell Differentiation
Pathways			RORA activates gene expression RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling
Drugs		Tretinoin Dexamethasone	Cholesterol-Sulfate Cholesterol
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Adult asthma ( 30787307) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Asthma ( 31361310 30929738 20860503 27182965 31619474 29273806) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Birth weight ( 31043758) Blood protein levels ( 28240269) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) Breast cancer (prognosis) ( 23319801) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic central serous retinopathy ( 30073298) Depression (quantitative trait) ( 20800221) Gamma glutamyl transferase levels ( 22010049) Height ( 31562340) High density lipoprotein cholesterol levels ( 31211820) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Male-pattern baldness ( 28196072) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Menarche (age at onset) ( 21102462 23599027 25231870) Multiple sclerosis ( 31604244) Neuropathic pain in head and neck cancer ( 29884837) Nickel levels ( 26025379) Offspring birth weight ( 31043758) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		16 interacting genes: AR COPS2 ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	23 interacting genes: BHLHE41 COPS5 CSNK1E EP300 GFAP HIF1A LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 SP1 ZXDC
Entrez ID		190	6095
HPRD ID		08362	02896
Ensembl ID		ENSG00000169297	ENSG00000069667
Uniprot IDs		F1D8P4 P51843	A0A0C4DFP5 A0A0C4DG53 P35398
PDB IDs		4RWV	1N83 1S0X 4S15
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?