NR0B1 and POU5F1

Number of citations of the paper that reports this interaction (PubMedID 19528230)
31

Data Source:
BioGRID (pull down)

		NR0B1	POU5F1
Description		nuclear receptor subfamily 0 group B member 1	POU class 5 homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck Centriolar Satellite Polysomal Ribosome Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity RNA Binding Nuclear Receptor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding DNA Hairpin Binding Steroid Hormone Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Steroid Biosynthetic Process Spermatogenesis Protein Localization Gonad Development Male Gonad Development Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Steroid Hormone Mediated Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Sertoli Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Blastocyst Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Cell Differentiation Somatic Stem Cell Population Maintenance MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Silencing By MiRNA
Pathways			POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs		Tretinoin Dexamethasone
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cold sores ( 28928442) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21801394) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Multiple myeloma ( 23955597) Night sleep phenotypes ( 27126917) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Type 2 diabetes ( 24509480 30718926 28869590) Ulcerative colitis ( 28067908)
Interacting Genes		16 interacting genes: AR COPS2 ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1	15 interacting genes: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH LRRK2 MNAT1 NR0B1 SOX10 SOX2 SOX8 STUB1 WDR5
Entrez ID		190	5460
HPRD ID		08362	01252
Ensembl ID		ENSG00000169297	ENSG00000204531
Uniprot IDs		F1D8P4 P51843	D2IYK3 F2Z381 M1S623 Q01860
PDB IDs		4RWV
Enriched GO Terms of Interacting Partners?
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