DHODH and MT2A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DHODH	MT2A
Description		dihydroorotate dehydrogenase (quinone)	metallothionein 2A
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Neuronal Cell Body	Cell Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Dihydroorotate Dehydrogenase Activity Drug Binding FMN Binding Ubiquinone Binding	Protein Binding Drug Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Female Pregnancy Lactation Pyrimidine Ribonucleotide Biosynthetic Process Response To Caffeine Response To Starvation Positive Regulation Of Apoptotic Process 'de Novo' UMP Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Oxidation-reduction Process Regulation Of Mitochondrial Fission Response To L-arginine	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Pyrimidine biosynthesis	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs		Leflunomide Atovaquone Orotic Acid Decylamine-N,N-Dimethyl-N-Oxide Riboflavin Monophosphate Brequinar Analog Brequinar Lauryl Dimethylamine-N-Oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-(AMINOCARBONYL)-1,1':4',1''-TERPHENYL-3-CARBOXYLICACID SC12267 (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide	Zinc
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bone mineral density (hip) ( 30172743) Fibrinogen levels ( 28107422) Hand grip strength ( 29691431) Low density lipoprotein cholesterol levels ( 29403010) Morning person ( 30696823) Number of sexual partners ( 30643258) Total cholesterol levels ( 29403010)
Interacting Genes		2 interacting genes: MT2A TMED10	20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25
Entrez ID		1723	4502
HPRD ID		00521	08863
Ensembl ID		ENSG00000102967	ENSG00000125148
Uniprot IDs		Q02127	P02795
PDB IDs		1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3W7R 3ZWS 3ZWT 4IGH 4JGD 4JS3 4JTS 4JTT 4JTU 4LS0 4LS1 4LS2 4OQV 4RK8 4RKA 4RLI 4RR4 4YLW 4ZL1 4ZMG 5H2Z 5H73 5HIN 5HQE 5K9C 5K9D 5MUT 5MVC 5MVD 5TCE 5ZF4 5ZF7 5ZF8 5ZF9 5ZFA 5ZFB 6CJF 6CJG 6ET4 6FMD 6GK0 6IDJ 6J3B 6J3C 6OC0 6OC1 6QU7 6SYP	1MHU 2MHU
Enriched GO Terms of Interacting Partners?
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