FAM9B and BARD1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FAM9B	BARD1
Description		family with sequence similarity 9 member B	BRCA1 associated RING domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex
	Molecular Function	Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Spermatogenesis Spermatid Development Meiotic Cell Cycle	DNA Double-strand Break Processing Tissue Homeostasis DNA Replication Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Protein Deubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Androgen levels ( 22936694) Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010) Hemoglobin ( 29403010) Male-pattern baldness ( 29146897 27182965) Metabolite levels ( 23823483)	Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)
Interacting Genes		123 interacting genes: ABT1 ACP6 ANKRD36B AP1M1 ASB6 ATF7 AURKAIP1 BAG6 BARD1 BCL2A1 BET1 BLOC1S2 BYSL C16orf72 C19orf57 C8orf33 CADPS CCDC106 CCDC116 CCDC198 CCDC70 CDC23 CDC42EP4 CDCA7L CENPL CEP57L1 CEP95 CHRAC1 CLCN1 CMTM6 COL20A1 CSDE1 CWF19L2 DAPK2 DAXX DENND2D DGUOK DNAJC15 DNAJC4 EBNA1BP2 ECH1 EIF3G ELOA FAM161A FASTKD3 FCHSD2 FERD3L FNDC11 GFOD1 GOPC GPX1 GSTK1 HNRNPLL ISCU LIN7A LINC02363 LMNA LNX1 LYRM2 MAB21L3 MFAP1 MOB1A MORF4L1 MORF4L2 MRPL10 MRPL28 MRPL9 MYG1 MYO15B NDE1 NDUFB10 NEBL NOL4 PAGE1 PAGE3 PHYH PIN4 POLL PPP1R18 PRPF3 PSMD14 PTRH1 RAB17 RAD51B RBM17 RBM23 RMND1 RPL9 RSL24D1 RUSC1 SDCBP SDCBP2 SERPINE2 SFN SLC16A3 SLPI SMARCB1 SMN2 SNAP29 SNAP47 SNX20 STK3 SUCLA2 SYT17 TBRG4 TCEA2 TCEANC TGFBI TRMT61B TSG101 TUFM TXN2 UBE2E2 URB1-AS1 WT1 XRCC4 YARS2 ZCCHC10 ZGPAT ZNF41 ZNF410 ZNF567 ZNF614	119 interacting genes: ACP1 ACSL3 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 CAP1 CASC1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCC DDX39B ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AX H2BC21 HAP1 HNRNPC HNRNPLL HSPA14 IDI1 ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RAD51 RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 WRN XRCC6 ZFP64 ZHX1 ZNF121
Entrez ID		171483	580
HPRD ID		15955	03354
Ensembl ID		ENSG00000177138	ENSG00000138376
Uniprot IDs		A0A024RBV3 Q8IZU0	A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728
PDB IDs			1JM7 2NTE 2R1Z 3C5R 3FA2
Enriched GO Terms of Interacting Partners?
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