BARD1 and KAT5

Number of citations of the paper that reports this interaction (PubMedID 15383276)
142

Data Source:
HPRD (two hybrid)

		BARD1	KAT5
Description		BRCA1 associated RING domain 1	lysine acetyltransferase 5
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex	Histone Acetyltransferase Complex Nuclear Chromatin Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity Acetyltransferase Activity Histone Binding Metal Ion Binding Androgen Receptor Binding Peptide-lysine-N-acetyltransferase Activity Repressing Transcription Factor Binding
	Biological Process	DNA Double-strand Break Processing Tissue Homeostasis DNA Replication Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Protein Deubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Positive Regulation Of Autophagy Viral Process Histone Acetylation Peptidyl-lysine Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Acetylation Beta-catenin-TCF Complex Assembly
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression
Drugs			Coenzyme A S-Acetyl-Cysteine
Diseases
GWAS		Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)	Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglycerides ( 30275531)
Interacting Genes		119 interacting genes: ACP1 ACSL3 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 CAP1 CASC1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCC DDX39B ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AX H2BC21 HAP1 HNRNPC HNRNPLL HSPA14 IDI1 ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RAD51 RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 WRN XRCC6 ZFP64 ZHX1 ZNF121	144 interacting genes: AGO2 ALOX12 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DNAAF6 DUSP23 E2F1 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL2 GOLGA2 GSTO1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 IK IKZF3 IL9R KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PFKP PHC2 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SRSF2 SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YIF1A YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513
Entrez ID		580	10524
HPRD ID		03354	03245
Ensembl ID		ENSG00000138376	ENSG00000172977
Uniprot IDs		A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728	A0A024R597 A0A024R5E8 Q92993
PDB IDs		1JM7 2NTE 2R1Z 3C5R 3FA2	2EKO 2OU2 4QQG
Enriched GO Terms of Interacting Partners?
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