DFFB and TOP2A

Number of citations of the paper that reports this interaction (PubMedID 10959840)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		DFFB	TOP2A
Description		DNA fragmentation factor subunit beta	DNA topoisomerase II alpha
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Protein-containing Complex	Nuclear Chromosome Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Complex (ATP-hydrolyzing) Viral Integration Complex Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	Deoxyribonuclease Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Disordered Domain Specific Binding	Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Drug Binding DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Protein Heterodimerization Activity
	Biological Process	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Chromosome Condensation	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation Cellular Response To DNA Damage Stimulus Chromosome Segregation Female Meiotic Nuclear Division Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Mitotic DNA Integrity Checkpoint Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of DNA Duplex Unwinding
Pathways		Apoptosis induced DNA fragmentation	Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins
Drugs			Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Levofloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin RTA 744 ZEN-012 Amrubicin Finafloxacin
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494) Metabolite levels ( 23823483)	Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		4 interacting genes: APP CIDEB DFFA TOP2A	29 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE
Entrez ID		1677	7153
HPRD ID		03532	00536
Ensembl ID		ENSG00000169598	ENSG00000131747
Uniprot IDs		B4DZS0 O76075 Q96P72 Q96P73 Q96P74	P11388
PDB IDs		1IBX	1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE
Enriched GO Terms of Interacting Partners?
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