TOP2A and FBXO28

Number of citations of the paper that reports this interaction (PubMedID 27754753)
3

Data Source:
BioGRID (pull down)

		TOP2A	FBXO28
Description		DNA topoisomerase II alpha	F-box protein 28
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Complex (ATP-hydrolyzing) Viral Integration Complex Protein-containing Complex Ribonucleoprotein Complex	Kinetochore Condensed Chromosome Kinetochore
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Drug Binding DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation Cellular Response To DNA Damage Stimulus Chromosome Segregation Female Meiotic Nuclear Division Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Mitotic DNA Integrity Checkpoint Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of DNA Duplex Unwinding
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Levofloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin RTA 744 ZEN-012 Amrubicin Finafloxacin
Diseases
GWAS		Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		29 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE	8 interacting genes: CSNK2A1 GK GOLGA2 PLEKHF2 SDCBP2 SPAG5 TOP2A TRAF2
Entrez ID		7153	23219
HPRD ID		00536	12367
Ensembl ID		ENSG00000131747	ENSG00000143756
Uniprot IDs		P11388	Q9NVF7
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE
Enriched GO Terms of Interacting Partners?
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