USP54 and HK1

		USP54	HK1
Description		ubiquitin specific peptidase 54	hexokinase 1
Image		No pdb structure
GO Annotations	Cellular Component		Cell Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft
	Molecular Function	Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Identical Protein Binding Peptidoglycan Binding
	Biological Process	Protein Deubiquitination	Cellular Glucose Homeostasis Positive Regulation Of Cytokine Secretion Involved In Immune Response Fructose 6-phosphate Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response Innate Immune Response Carbohydrate Phosphorylation Positive Regulation Of Interleukin-1 Beta Secretion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion
Pathways			Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs			alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS			Birth weight ( 31043758) Glycated hemoglobin levels ( 20858683 31213470 19096518 28898252) Glycemic traits (pregnancy) ( 23903356) Hematocrit ( 27863252 19862010) Hemoglobin ( 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Ischemic stroke (cardioembolic) ( 29531354) Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 20139978 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 20139978 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		21 interacting genes: ARID5B ATN1 ATXN1 CDK19 CFAP70 CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 EIF4E2 FAM149B1 FUT11 HK1 MSS51 MSX2 NXT2 PLCD1 SAMD8 TTYH1 UBC	6 interacting genes: APP ENO2 SCMH1 USP54 VDAC1 VDAC2
Entrez ID		159195	3098
HPRD ID		15641	00809
Ensembl ID		ENSG00000166348	ENSG00000156515
Uniprot IDs		B7Z7X1 Q70EL1	A0A024QZK7 A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs			1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?