HSCB and ISCU

Number of citations of the paper that reports this interaction (PubMedID 24573684)
9

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HSCB	ISCU
Description		HscB mitochondrial iron-sulfur cluster cochaperone	iron-sulfur cluster assembly enzyme
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cell Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	ATPase Activator Activity Molecular_function Protein Binding Identical Protein Binding Metal Ion Binding Chaperone Binding	Iron Ion Binding Protein Binding Ferrous Iron Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Molecular Adaptor Activity
	Biological Process	Iron-sulfur Cluster Assembly Positive Regulation Of ATPase Activity [2Fe-2S] Cluster Assembly Protein Complex Oligomerization Protein Maturation By Iron-sulfur Cluster Transfer	Cellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly Small Molecule Metabolic Process Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Aconitate Hydratase Activity Negative Regulation Of Ferrous Iron Import Across Plasma Membrane
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis
Drugs
Diseases
GWAS		Breast size ( 27182965) Diastolic blood pressure ( 27841878) Esophageal cancer and gastric cancer ( 20729852) Pancreatic cancer ( 25086665) Red cell distribution width ( 27863252) Systolic blood pressure ( 27841878)	Acne (severe) ( 24927181) Intraocular pressure ( 29617998)
Interacting Genes		6 interacting genes: AGTRAP BBS1 BBS2 BBS4 FBN1 ISCU	13 interacting genes: AGTRAP BANP CCDC172 FAM9B GOLGA2 HPRT1 HSCB IKZF1 KRT40 LNX1 MID2 NECAB2 NUP62
Entrez ID		150274	23479
HPRD ID		16289	14828
Ensembl ID		ENSG00000100209	ENSG00000136003
Uniprot IDs		A0A384NYJ4 B0QYH2 Q8IWL3	A0A024RBI3 B1P7G3 B3KQ30 B4DNC9 Q9H1K1
PDB IDs		3BVO	5KZ5 5WKP 5WLW 6NZU 6UXE
Enriched GO Terms of Interacting Partners?
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