SIK1 and GINS4

Number of citations of the paper that reports this interaction (PubMedID 27592030)
2

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		SIK1	GINS4
Description		salt inducible kinase 1	GINS complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	GINS Complex Nucleoplasm Cytoplasm Replication Fork Protection Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding	Protein Binding 3'-5' DNA Helicase Activity
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding
Pathways		Circadian Clock	Unwinding of DNA Unwinding of DNA
Drugs		Dabrafenib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27841878 28739976 27618452)
Interacting Genes		13 interacting genes: CRTC2 GINS4 HDAC5 MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ	9 interacting genes: CDC45 GINS1 GINS2 GINS3 MCM2 POLA1 POLD1 POLE SIK1
Entrez ID		150094	84296
HPRD ID		09301	11583
Ensembl ID		ENSG00000142178	ENSG00000147536
Uniprot IDs		P57059	Q9BRT9
PDB IDs			2E9X 2EHO 2Q9Q
Enriched GO Terms of Interacting Partners?
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