CRYBA4 and GLI1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		CRYBA4	GLI1
Description		crystallin beta A4	GLI family zinc finger 1
Image
GO Annotations	Cellular Component	Cellular_component	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base
	Molecular Function	Molecular_function Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Lens Development In Camera-type Eye Visual Perception Camera-type Eye Development	Osteoblast Differentiation Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation
Pathways			Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS
Interacting Genes		13 interacting genes: C1orf94 CCDC33 CEP76 CRYBB1 CRYBB2 EFEMP1 FHL5 GLI1 IKZF3 MIF4GD PRR22 STX11 TRIP6	18 interacting genes: CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT5 RAI1 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2
Entrez ID		1413	2735
HPRD ID		00432	01311
Ensembl ID		ENSG00000196431	ENSG00000111087
Uniprot IDs		A0A097PIJ6 P53673	B4DNF7 P08151
PDB IDs		3LWK	2GLI 4BLB 4KMD 5OM0
Enriched GO Terms of Interacting Partners?
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