NUCB1 and PTGS1

Number of citations of the paper that reports this interaction (PubMedID 8643612)
18

Data Source:
HPRD (in vitro, two hybrid)

		NUCB1	PTGS1
Description		nucleobindin 1	prostaglandin-endoperoxide synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi-associated Vesicle Cis-Golgi Network Trans-Golgi Network Membrane Golgi Cisterna Membrane Extracellular Exosome Extrinsic Component Of Golgi Membrane Lumenal Side Of Golgi Membrane	Photoreceptor Outer Segment Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Heme Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Small GTPase Mediated Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Response To Cisplatin Regulation Of Protein Targeting	Prostaglandin Biosynthetic Process Xenobiotic Metabolic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Cyclooxygenase Pathway Regulation Of Cell Proliferation Oxidation-reduction Process Cellular Oxidant Detoxification
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Calcium Citrate Calcium Phosphate	Dihomo-gamma-linolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Antrafenine Antipyrine Tiaprofenic acid O-acetyl-L-serine Hyperforin 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic Acid Beta-D-Glucose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Acetic Acid Salicyloyl-Amino-Ester P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic Acid Arachidonic Acid Metamizole Lornoxicam Aceclofenac Nepafenac 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Triflusal Dexibuprofen Nitroaspirin Acemetacin
Diseases
GWAS			Glomerular filtration rate in chronic kidney disease ( 26420894)
Interacting Genes		17 interacting genes: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 MYC NDN PLOD2 PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1	3 interacting genes: NCL NUCB1 PTGIS
Entrez ID		4924	5742
HPRD ID		03205	07518
Ensembl ID		ENSG00000104805	ENSG00000095303
Uniprot IDs		A8K7Q1 Q02818	A0A087X296 P23219
PDB IDs		1SNL
Enriched GO Terms of Interacting Partners?
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