ADAMTS14 and DDX21

		ADAMTS14	DDX21
Description		ADAM metallopeptidase with thrombospondin type 1 motif 14	DExD-box helicase 21
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane
	Molecular Function	Metalloendopeptidase Activity Metal Ion Binding	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Proteolysis Collagen Fibril Organization Collagen Catabolic Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Moderate-to-late spontaneous preterm birth ( 31194736) Optic disc size ( 31809533) Sleep duration ( 23728906) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Suicide behavior ( 26079190)	Depression (quantitative trait) ( 20800221)
Interacting Genes		1 interacting genes: DDX21	18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I
Entrez ID		140766	9188
HPRD ID		06329	05895
Ensembl ID		ENSG00000138316	ENSG00000165732
Uniprot IDs		Q8WXS8	Q9NR30
PDB IDs			2M3D
Enriched GO Terms of Interacting Partners?
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