UBXN2B and CRX

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		UBXN2B	CRX
Description		UBX domain protein 2B	cone-rod homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Spindle Pole Centrosome	Nuclear Chromatin Nucleus
	Molecular Function	Protein Binding Ubiquitin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome	Regulation Of Transcription, DNA-templated Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Stimulus
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		7 interacting genes: CRX INCA1 MEOX1 NGLY1 PPP1R11 VAT1L VCP	54 interacting genes: ABI2 ACBD4 ATG12 ATM ATXN7 BANF1 BANP C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 DELE1 EIF5A EP300 GCM2 GUCD1 HGS IPO13 KAT2A KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PDC PICALM PID1 PPP1R16B PRKAB2 PRKN PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS ROR2 SFI1 SMAD3 SMUG1 SOX5 STK16 SZT2 TLE5 UBXN2B ZNF688
Entrez ID		137886	1406
HPRD ID		18973	03748
Ensembl ID		ENSG00000215114	ENSG00000105392
Uniprot IDs		E5RJ36 Q14CS0	O43186
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?