STIP1 and MAP3K8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		STIP1	MAP3K8
Description		stress induced phosphoprotein 1	mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Nucleus Golgi Apparatus Cytosol Protein-containing Complex Chaperone Complex	Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Hsp70 Protein Binding Chaperone Binding Hsp90 Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Cellular Response To Interleukin-7	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Copper
Diseases
GWAS		Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: ACD ACVR1 AIP APP CDC37 CLCN1 CLK1 EGFR FKBP4 FKBP5 HSP90AA1 HSPA14 HSPA1A HSPA8 LMO2 LRRK2 MAP3K8 POT1 PRNP PTGES3 SUMO4 YIF1A	17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		10963	1326
HPRD ID		05454	01863
Ensembl ID		ENSG00000168439	ENSG00000107968
Uniprot IDs		P31948 V9HW72	P41279 Q6FG25
PDB IDs		1ELR 1ELW 2LNI 2NC9 3ESK 3FWV	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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