COL4A5 and DCN

Number of citations of the paper that reports this interaction (PubMedID 10382266)
38

Data Source:
HPRD (in vivo)

		COL4A5	DCN
Description		collagen type IV alpha 5 chain	decorin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix	Extracellular Region Collagen Type VI Trimer Extracellular Space Golgi Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	RNA Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein N-terminus Binding Extracellular Matrix Binding
	Biological Process	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Kidney Development Placenta Development Skeletal Muscle Tissue Development Aging Response To Mechanical Stimulus Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs	Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs			Tromethamine
Diseases		Alport syndrome	Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS			Blood protein levels ( 30072576) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Sudden cardiac arrest ( 21658281)
Interacting Genes		19 interacting genes: ANTXR2 ANXA7 APP CD93 CDKN1A DAZAP2 DCN FBLN2 FN1 GLA HABP2 MATN2 MMP9 NR1H2 OSM RNF10 SERPINE2 SMN1 TK1	30 interacting genes: AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF
Entrez ID		1287	1634
HPRD ID		02363	00501
Ensembl ID		ENSG00000188153	ENSG00000011465
Uniprot IDs		A7MBN3 P29400 Q49AM6	A0A024RBG6 P07585 Q6FH10
PDB IDs		5NAZ
Enriched GO Terms of Interacting Partners?
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