DCN and COL5A1

Number of citations of the paper that reports this interaction (PubMedID 8440685)
7

Data Source:
HPRD (in vitro)

		DCN	COL5A1
Description		decorin	collagen type V alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Golgi Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Collagen Type V Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein N-terminus Binding Extracellular Matrix Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Kidney Development Placenta Development Skeletal Muscle Tissue Development Aging Response To Mechanical Stimulus Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Extracellular Matrix Organization Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation
Pathways		Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs		Tromethamine
Diseases		Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Sudden cardiac arrest ( 21658281)	Blood pressure ( 24954895) Central corneal thickness ( 28171582 22814818 31798171 23493294 29760442 30894546 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intraocular pressure ( 29617998) Longevity ( 20834067) Metabolite levels ( 23823483) Phosphatidylcholine levels ( 31551469)
Interacting Genes		30 interacting genes: AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF	10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1
Entrez ID		1634	1289
HPRD ID		00501	00368
Ensembl ID		ENSG00000011465	ENSG00000130635
Uniprot IDs		A0A024RBG6 P07585 Q6FH10	A0A024R8E5 B2ZZ86 P20908 Q59EE7
PDB IDs			1A89 1A9A
Enriched GO Terms of Interacting Partners?
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