GRIN3A and DYNLL1

Number of citations of the paper that reports this interaction (PubMedID 14760703)
28

Data Source:
HPRD (in vitro)

		GRIN3A	DYNLL1
Description		glutamate ionotropic receptor NMDA type subunit 3A	dynein light chain LC8-type 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane
	Molecular Function	NMDA Glutamate Receptor Activity Calcium Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity Glycine Binding Signaling Receptor Activity Identical Protein Binding Protein Phosphatase 2A Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Calcium Ion Transport Dendrite Development Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Prepulse Inhibition Calcium Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis	G2/M Transition Of Mitotic Cell Cycle ER To Golgi Vesicle-mediated Transport Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Phosphorylation Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways		Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors	Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Glutamic Acid Tramadol Atomoxetine Pentobarbital Methadone Ethopropazine Secobarbital Dextromethorphan Acamprosate Procaine Ethanol Amantadine Felbamate Gabapentin Memantine Halothane Chloroprocaine Orphenadrine Phenobarbital Ketamine Tenocyclidine Rolicyclidine Prasterone Phencyclidine Milnacipran Neramexane Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Asthma ( 27611488) Coronary artery aneurysm in Kawasaki disease ( 26434682) Coronary artery calcification ( 23870195) Glucocorticoid-induced osteonecrosis ( 26265699) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Response to fenofibrate (triglyceride levels) ( 27002377) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		6 interacting genes: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B PTPA	79 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF CA2 CACNB1 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 ERG28 GAPDH GLUD1 GLUL GPHN GRIN3A HIP1R HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RACK1 RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A
Entrez ID		116443	8655
HPRD ID		09443	03334
Ensembl ID		ENSG00000198785	ENSG00000088986
Uniprot IDs		Q8TCU5	P63167 Q6FGH9
PDB IDs			1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2
Enriched GO Terms of Interacting Partners?
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