AKAP11 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 10864471)
32

Data Source:
HPRD (in vivo)

		AKAP11	PRKAR1A
Description		A-kinase anchoring protein 11	protein kinase cAMP-dependent type I regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Peroxisome Microtubule Organizing Center Cytosol Plasma Membrane	Immunological Synapse Cytoplasm Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Ciliary Base Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Movement Of Cell Or Subcellular Component Protein Localization Intracellular Signal Transduction	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Cyclic Guanosine Monophosphate Cyclic Adenosine Monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740) Bone mineral density (spine) ( 19801982) Crohn's disease ( 28067908) Hepcidin levels ( 27846281) Inflammatory bowel disease ( 28067908) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401)	Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)
Interacting Genes		6 interacting genes: GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B	40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		11215	5573
HPRD ID		05261	01786
Ensembl ID		ENSG00000023516	ENSG00000108946
Uniprot IDs		Q9UKA4	B2R5T5 P10644
PDB IDs			5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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