STRAP and NXF1

Number of citations of the paper that reports this interaction (PubMedID 22658674)
627

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		STRAP	NXF1
Description		serine/threonine kinase receptor associated protein	nuclear RNA export factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex	Transcription Export Complex Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Speck Nuclear Inclusion Body
	Molecular Function	RNA Binding Signaling Receptor Binding Protein Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spliceosomal SnRNP Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	RNA Export From Nucleus MRNA Export From Nucleus Viral Process Poly(A)+ MRNA Export From Nucleus
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		24 interacting genes: CHEK2 GEMIN6 GEMIN7 MAP1B MTRES1 NXF1 PBLD PDPK1 RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO4 TGFBR1 TGFBR2	54 interacting genes: ALYREF CSNK2A1 DHX9 DVL3 EIF4A3 ELAVL4 ESRRA GFAP HNRNPUL1 IMPA1 IPO11 IPO4 KCTD5 KRT40 LDOC1 LUZP4 MAGOH MAP1A MAP1B MARK2 MID2 NUP153 NUP214 NUP62 NUP98 NXF2 NXF3 NXF5 NXT1 NXT2 RAD51 RAE1 RAN RANBP2 RBM15B RBM8A SGTA SH2D3A SRPK2 SRSF1 SRSF3 SRSF7 STRAP THOC5 TIFA TNPO1 TNPO2 TRA2A TRA2B U2AF1 UBQLN4 UPF3A XIST ZBED2
Entrez ID		11171	10482
HPRD ID		05816	04035
Ensembl ID		ENSG00000023734	ENSG00000162231
Uniprot IDs		B0AZV0 Q9Y3F4	Q59E96 Q9UBU9
PDB IDs			1FO1 1FT8 1GO5 1JKG 1JN5 1KOH 1KOO 1OAI 2Z5K 2Z5M 3RW6 3RW7 4WYK 6E5U
Enriched GO Terms of Interacting Partners?
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