NUDT3 and CCL11

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		NUDT3	CCL11
Description		nudix hydrolase 3	C-C motif chemokine ligand 11
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Cell
	Molecular Function	Magnesium Ion Binding Endopolyphosphatase Activity Diphosphoinositol-polyphosphate Diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity M7G(5')pppN Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Diphosphoinositol Polyphosphate Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline
Pathways		Synthesis of pyrophosphates in the cytosol	Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs			CAT-213
Diseases
GWAS		Atrial fibrillation ( 29892015) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 30604766) Height ( 25429064 19893584 31562340) Hip circumference ( 25673412)	Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		36 interacting genes: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1	7 interacting genes: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1
Entrez ID		11165	6356
HPRD ID		14849	03098
Ensembl ID		ENSG00000272325	ENSG00000172156
Uniprot IDs		O95989	P51671 Q6I9T4
PDB IDs		2FVV 2Q9P	1EOT 2EOT 2MPM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?