CHGA and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		CHGA	PFDN1
Description		chromogranin A	prefoldin subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Transport Vesicle Membrane Chromaffin Granule Mast Cell Granule Perinuclear Region Of Cytoplasm Neuronal Dense Core Vesicle	Prefoldin Complex
	Molecular Function		DNA-binding Transcription Factor Activity Protein Binding Protein Binding Involved In Protein Folding Unfolded Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Mast Cell Chemotaxis Organelle Organization Regulation Of Blood Pressure Antimicrobial Humoral Response Killing Of Cells Of Other Organism Mast Cell Cytokine Production Protein Localization To Secretory Granule Negative Regulation Of Catecholamine Secretion Defense Response To Bacterium Mast Cell Degranulation Innate Immune Response Mast Cell Activation Negative Regulation Of Insulin Secretion Negative Regulation Of Hormone Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Cardiac Muscle Relaxation Negative Regulation Of Blood Vessel Diameter Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Dense Core Granule Biogenesis	Regulation Of Transcription, DNA-templated Protein Folding
Pathways		Antimicrobial peptides	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		6 interacting genes: CDC37 NEK2 PFDN1 PLG SCG3 UBC	53 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		1113	5201
HPRD ID		07170	05357
Ensembl ID		ENSG00000100604	ENSG00000113068
Uniprot IDs		G5E968 P10645 Q86T07	O60925
PDB IDs		1LV4	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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