RPP14 and DOCK7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		RPP14	DOCK7
Description		ribonuclease P/MRP subunit p14	dedicator of cytokinesis 7
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex	Focal Adhesion COP9 Signalosome Axon Growth Cone Neuron Projection Basal Part Of Cell
	Molecular Function	Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac GTPase Binding
	Biological Process	TRNA 5'-leader Removal RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Microtubule Cytoskeleton Organization Small GTPase Mediated Signal Transduction Axonogenesis Interkinetic Nuclear Migration Neuron Projection Development Positive Regulation Of Peptidyl-serine Phosphorylation Establishment Of Neuroblast Polarity Regulation Of Neurogenesis Activation Of GTPase Activity Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	MET activates RAP1 and RAC1 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Height ( 28552196) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)	Cholesterol, total ( 28270201 19060911 25961943 20686565) Crohn's disease ( 28067908) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 19060911 30275531 25961943 20686565) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483 22916037) Metabolite levels (lipid measures) ( 27005778) Platelet distribution width ( 27863252) Pneumococcal bacteremia ( 27236921) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 29403010 30275531) Triglyceride levels ( 31170924 29403010 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 20864672 19060911 25961943 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		19 interacting genes: A2M ATP5F1B CAPZB DOCK7 EXOSC8 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ	16 interacting genes: ANXA7 BCL2L1 CDC42 CDKN1A GRB7 NOD2 NSD3 PPP2CB PRNP RAC1 RHOA RPP14 SMN1 SNCA TK1 YWHAG
Entrez ID		11102	85440
HPRD ID		18001	16833
Ensembl ID		ENSG00000163684	ENSG00000116641
Uniprot IDs		O95059	Q96N67
PDB IDs		6AHR 6AHU	6AJ4 6AJL
Enriched GO Terms of Interacting Partners?
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