RPP14 and MSH2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		RPP14	MSH2
Description		ribonuclease P/MRP subunit p14	mutS homolog 2
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex
	Molecular Function	Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	TRNA 5'-leader Removal RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Ovarian cancer
GWAS		Height ( 28552196) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)	Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		19 interacting genes: A2M ATP5F1B CAPZB DOCK7 EXOSC8 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ	33 interacting genes: AKT1 ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP EPHA2 ESR1 ESR2 EXO1 FGFR4 GRB7 HDAC6 HUS1 MAX MSH3 MSH6 MYC PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 SUMO2 TK1 TREX1 TRIM29 USP10 XPA
Entrez ID		11102	4436
HPRD ID		18001	00389
Ensembl ID		ENSG00000163684	ENSG00000095002
Uniprot IDs		O95059	A0A2R8Y6P0 P43246
PDB IDs		6AHR 6AHU	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?