TRIM31 and NLRP3

Number of citations of the paper that reports this interaction (PubMedID 27929086)
38

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		TRIM31	NLRP3
Description		tripartite motif containing 31	NLR family pyrin domain containing 3
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GO Annotations	Cellular Component	Mitochondrion Cytosol Nuclear Body	Golgi Membrane Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity	Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Peptidoglycan Binding Sequence-specific DNA Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Viral Transcription Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell	Cytokine Secretion Involved In Immune Response Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Interleukin-18 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Interleukin-1 Secretion Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Interferon gamma signaling	Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 28240269) Estimated glomerular filtration rate in diabetes ( 31451708) Isovolumetric relaxation time ( 28394258) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	C-reactive protein levels ( 30388399 21300955) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Platelet count ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252) Word reading ( 23738518)
Interacting Genes		21 interacting genes: EID3 IKBKG MAGEA1 MAGEA2B MKRN3 MNAT1 NLRP3 NSMCE4A TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2W USP7 ZSCAN1	8 interacting genes: ATP1B3 CARD8 CUL1 FAF1 FBXL2 PGM1 PYCARD TRIM31
Entrez ID		11074	114548
HPRD ID		10281	05915
Ensembl ID		ENSG00000204616	ENSG00000162711
Uniprot IDs		Q2L6J1 Q9BZY9	Q96P20
PDB IDs		2YSJ 2YSL	2NAQ 3QF2 6NPY
Enriched GO Terms of Interacting Partners?
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