NLRP3 and FAF1

Number of citations of the paper that reports this interaction (PubMedID 17046979)
11

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NLRP3	FAF1
Description		NLR family pyrin domain containing 3	Fas associated factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol NLRP3 Inflammasome Complex	Nucleus Nuclear Envelope Nucleoplasm Cytosol CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Peptidoglycan Binding Sequence-specific DNA Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Cytokine Secretion Involved In Immune Response Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Interleukin-18 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Interleukin-1 Secretion Negative Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of T-helper 2 Cell Cytokine Production	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process
Pathways		Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		C-reactive protein levels ( 30388399 21300955) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Platelet count ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252) Word reading ( 23738518)	Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Lung function (FEV1/FVC) ( 30804560) Male-pattern baldness ( 28196072) Multisite chronic pain ( 31194737) Peak expiratory flow ( 30804560) Pulse pressure ( 27841878 30578418) QRS duration ( 30679814 21076409) Renal cell carcinoma ( 28598434) Type 2 diabetes ( 24509480 30297969 26818947 30718926 28869590) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		8 interacting genes: ATP1B3 CARD8 CUL1 FAF1 FBXL2 PGM1 PYCARD TRIM31	44 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD XIAP
Entrez ID		114548	11124
HPRD ID		05915	05124
Ensembl ID		ENSG00000162711	ENSG00000185104
Uniprot IDs		Q96P20	Q9UNN5
PDB IDs		2NAQ 3QF2 6NPY	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?
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