MID2 and UBE2E2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		MID2	UBE2E2
Description		midline 2	ubiquitin conjugating enzyme E2 E2
Image
GO Annotations	Cellular Component	Cytoplasm Microtubule Extracellular Exosome
	Molecular Function	Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Homodimerization Activity Phosphoprotein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Viral Transcription Protein Localization To Microtubule Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Psychosis (atypical) ( 24132900) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 30718926 28869590) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)
Interacting Genes		118 interacting genes: ADAMTSL4 AEN AQP1 ATRIP AXIN1 BCL6B BRCA1 BRMS1L BYSL CALCOCO2 CBX8 CCDC120 CCDC42 CCHCR1 CEP57L1 CHD2 COX5B CTSZ DCX DGCR6 DGCR6L DMRT3 DYDC1 ELOA FAM107A FAM161A FAM214A FAM90A1 FARS2 FBF1 FBXL18 FRMD6 GFI1B GMCL1 GOLGA2 GORASP2 HNRNPLL HOXB9 IGBP1 IQCN ISCU JOSD1 KIF1A KIFC3 LENG1 LGALS14 LGALS8 MAGOHB METTL17 MFAP1 MID1 MID1IP1 MOS MVP NR1D2 NXF1 OTUB2 PPP1R18 PRPF3 PRPF31 PSMA1 PTCD2 RCOR3 RNF6 RPH3AL RPP25L RUNX1T1 RXRB SCNM1 SDCBP SHFL SLC25A48 SLC25A6 SNAI1 SNAP47 SPAG5 SPATA24 SPG21 SPRY2 STX11 TCAF1 TCEA2 THAP7 TMEM14B TOP3B TRIM27 TRIM29 TRIM32 TRIM42 TRIM54 TRPV6 TSGA10 UBE2D1 UBE2D4 UBE2E2 UBE2E3 UBE2U UBTD1 UNC45A UTP23 UTP25 WT1-AS ZBTB24 ZC2HC1C ZFYVE21 ZGPAT ZNF165 ZNF24 ZNF250 ZNF417 ZNF440 ZNF564 ZNF587 ZNF688 ZNF774 ZNF785 ZNF792 ZSCAN12	68 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFE2L2 PCGF2 PDLIM2 PRAM1 PRKN RBX1 RC3H2 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1
Entrez ID		11043	7325
HPRD ID		02191	06779
Ensembl ID		ENSG00000080561	ENSG00000182247
Uniprot IDs		Q6GX22 Q9UJV3	Q96LR5
PDB IDs		2DJA 2DMK	1Y6L
Enriched GO Terms of Interacting Partners?
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