UBE2E2 and MID1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid, two hybrid)

		UBE2E2	MID1
Description		ubiquitin conjugating enzyme E2 E2	midline 1
Image
GO Annotations	Cellular Component		Spindle Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Phosphoprotein Binding
	Biological Process	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Interferon-gamma-mediated Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases			Opitz-GBBB syndrome
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Psychosis (atypical) ( 24132900) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 30718926 28869590) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)
Interacting Genes		68 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFE2L2 PCGF2 PDLIM2 PRAM1 PRKN RBX1 RC3H2 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1	33 interacting genes: BYSL DYRK4 EHHADH FKBP1A GMCL1 HMG20B HTT IGBP1 MEOX1 MID1IP1 MID2 OTUB2 PAX6 PKN1 PPP2CA PPP2CB PTPA SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1
Entrez ID		7325	4281
HPRD ID		06779	02047
Ensembl ID		ENSG00000182247	ENSG00000101871
Uniprot IDs		Q96LR5	A0A024RBV4 A0A087X0X0 A0A087X255 O15344
PDB IDs		1Y6L	2DQ5 2FFW 2JUN 5IM8
Enriched GO Terms of Interacting Partners?
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