MORF4L1 and CAMK2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MORF4L1	CAMK2B
Description		mortality factor 4 like 1	calcium/calmodulin dependent protein kinase II beta
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Sin3 Complex Nuclear Speck NuA4 Histone Acetyltransferase Complex	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Cell Junction Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse
	Molecular Function	Chromatin Binding Protein Binding Protein N-terminus Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Chromatin Silencing Cell Proliferation Histone Acetylation Histone Deacetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration
Pathways		HATs acetylate histones	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants
Drugs			[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Diseases
GWAS		Coronary artery disease ( 30104761) Coronary heart disease ( 21378988) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878 30578418) Squamous cell lung carcinoma ( 28604730)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418)
Interacting Genes		42 interacting genes: APP ARRDC3 BEND7 CALM1 CAMK2B CEP57L1 EP300 FAM9B FHL3 FXR2 GMCL1 GOLGA2 H3-4 HINFP HMBOX1 IKZF1 L3MBTL3 LMNA LZTS2 MEOX1 MRFAP1 MRFAP1L1 MRGBP MSL1 NAB2 NAV2 NMI PBXIP1 PHF12 PSMC1 RACGAP1 RB1 REL SH3GLB2 TEX11 TFCP2 THAP1 TNIP1 TNNT1 TRIM41 ZBTB10 ZBTB9	38 interacting genes: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB ZBTB32
Entrez ID		10933	816
HPRD ID		09532	12127
Ensembl ID		ENSG00000185787	ENSG00000058404
Uniprot IDs		Q9UBU8	A4D2J9 B7Z1Z6 Q13554
PDB IDs		2AQL 2EFI 2F5J 2F5K 2LKM 2N1D 6AGO 6INE	3BHH
Enriched GO Terms of Interacting Partners?
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