CAMK2B and RXRG

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
HPRD (two hybrid)

		CAMK2B	RXRG
Description		calcium/calmodulin dependent protein kinase II beta	retinoid X receptor gamma
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Cell Junction Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants	Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs		[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile	Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Etretinate Bezafibrate Phthalic Acid Doconexent
Diseases
GWAS		Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418)	AIDS ( 19754311) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Macular thickness ( 30535121) Menarche (age at onset) ( 27182965 21102462 29773799 25231870) Metabolite levels ( 23823483) Personality traits in bipolar disorder ( 21368711)
Interacting Genes		38 interacting genes: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB ZBTB32	29 interacting genes: CAMK2B CEBPZ CHGB CREBBP DCK HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR
Entrez ID		816	6258
HPRD ID		12127	01579
Ensembl ID		ENSG00000058404	ENSG00000143171
Uniprot IDs		A4D2J9 B7Z1Z6 Q13554	A0A087WZ88 F1D8Q7 F1T097 P48443
PDB IDs		3BHH	2GL8
Enriched GO Terms of Interacting Partners?
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