GADD45G and SERPINA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		GADD45G	SERPINA4
Description		growth arrest and DNA damage inducible gamma	serpin family A member 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade	Platelet Degranulation Negative Regulation Of Endopeptidase Activity
Pathways			Platelet degranulation
Drugs			Zinc Copper
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Automobile speeding propensity ( 30643258) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638)	Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)
Interacting Genes		55 interacting genes: AFAP1L1 APP ARPC5L CCNB1 CDK1 CDKN1A CEP57L1 CRIP2 DDAH2 EEF1A1 EEF1G EIF3G ESR1 EZH2 GADD45B GADD45GIP1 GDF9 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RBM48 RDH13 REL RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579	13 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		10912	5267
HPRD ID		05383	01004
Ensembl ID		ENSG00000130222	ENSG00000100665
Uniprot IDs		O95257	A0A024R6I9 P29622
PDB IDs		2WAL 3FFM	6F02
Enriched GO Terms of Interacting Partners?
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