GADD45G and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		GADD45G	DDAH2
Description		growth arrest and DNA damage inducible gamma	dimethylarginine dimethylaminohydrolase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Cytosol Centriolar Satellite Extracellular Exosome
	Molecular Function	Protein Binding	Catalytic Activity Protein Binding Dimethylargininase Activity Amino Acid Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines
	Biological Process	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade	Citrulline Metabolic Process Arginine Metabolic Process Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity
Pathways			eNOS activation
Drugs			L-Citrulline
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Automobile speeding propensity ( 30643258) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		55 interacting genes: AFAP1L1 APP ARPC5L CCNB1 CDK1 CDKN1A CEP57L1 CRIP2 DDAH2 EEF1A1 EEF1G EIF3G ESR1 EZH2 GADD45B GADD45GIP1 GDF9 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RBM48 RDH13 REL RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579	22 interacting genes: ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 GADD45G MAP3K20 MKNK1 PIN1 RAP1B RCC1 RPS6KA1 RPS6KA5 SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		10912	23564
HPRD ID		05383	09204
Ensembl ID		ENSG00000130222	ENSG00000213722
Uniprot IDs		O95257	O95865 V9HW53
PDB IDs		2WAL 3FFM
Enriched GO Terms of Interacting Partners?
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