USP39 and TRIM5

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		USP39	TRIM5
Description		ubiquitin specific peptidase 39	tripartite motif containing 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	P-body Nucleus Cytoplasm Cytosol Omegasome
	Molecular Function	Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Binding, Bridging Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Cell Division	Activation Of Innate Immune Response Autophagy Viral Process Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		mRNA Splicing - Major Pathway	Interferon gamma signaling
Drugs
Diseases
GWAS		Neurofibrillary tangles ( 31497858)	Coronary artery disease ( 29212778) DNA methylation (variation) ( 23725790) Mean platelet volume ( 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		13 interacting genes: ACVR1 APP LRRK2 SAE1 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8	38 interacting genes: BTBD1 BTBD2 EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5
Entrez ID		10713	85363
HPRD ID		07165	07004
Ensembl ID		ENSG00000168883	ENSG00000132256
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	Q9C035
PDB IDs		3JCR 6AH0 6QW6 6QX9	2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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