USP39 and TRIM25

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		USP39	TRIM25
Description		ubiquitin specific peptidase 39	tripartite motif containing 25
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body
	Molecular Function	Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Cell Division	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor
Pathways		mRNA Splicing - Major Pathway	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Neurofibrillary tangles ( 31497858)	Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		13 interacting genes: ACVR1 APP LRRK2 SAE1 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8	36 interacting genes: AMFR APC ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 ZC3HAV1 ZNF24
Entrez ID		10713	7706
HPRD ID		07165	02711
Ensembl ID		ENSG00000168883	ENSG00000121060
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	Q14258
PDB IDs		3JCR 6AH0 6QW6 6QX9	4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?
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