RRAGA and RPTOR

Number of citations of the paper that reports this interaction (PubMedID 18497260)
945

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		RRAGA	RPTOR
Description		Ras related GTP binding A	regulatory associated protein of MTOR complex 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Cytosol EGO Complex GATOR1 Complex Gtr1-Gtr2 GTPase Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body
	Molecular Function	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Phosphoprotein Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein Binding, Bridging Protein-containing Complex Binding 14-3-3 Protein Binding
	Biological Process	Apoptotic Process Cell Cycle Arrest Cell Death Cellular Response To Starvation Regulation Of Autophagy Negative Regulation Of Autophagy Regulation Of Macroautophagy Protein Ubiquitination Modulation By Virus Of Host Morphology Or Physiology Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Cellular Response To Amino Acid Stimulus Positive Regulation Of TORC1 Signaling	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Regulation Of Cell Size Cellular Response To Starvation Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Viral Process Regulation Of Macroautophagy Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes E3 ubiquitin ligases ubiquitinate target proteins Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy mTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS			Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		5 interacting genes: IL7R NOL8 RNF152 RPTOR RRAGC	22 interacting genes: CILK1 DUXAP9 EIF4EBP1 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB WIPI2
Entrez ID		10670	57521
HPRD ID		10205	06184
Ensembl ID		ENSG00000155876	ENSG00000141564
Uniprot IDs		Q7L523	Q6DKI0 Q8N122
PDB IDs		5X6V 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG	5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?