POLR3F and NINL

		POLR3F	NINL
Description		RNA polymerase III subunit F	ninein like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex Cytosol	Centrosome Cytosol Microtubule Intercellular Bridge
	Molecular Function	Double-stranded DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase III Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Anchoring At Centrosome Ciliary Basal Body-plasma Membrane Docking
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)
Interacting Genes		15 interacting genes: BDP1 BRF1 ERG28 GTF3C4 KAT5 LRIF1 NINL PRPF4B RIN3 STC2 SUV39H2 TBP TNS2 UBE2G2 WDR89	50 interacting genes: AKAP17A APEX2 APMAP AURKB CBY2 CCDC130 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 POLR3F RBM41 RCOR3 RGS2 RIBC2 SEC23B SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSPYL4 UTP14A ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		10621	22981
HPRD ID		15156	11120
Ensembl ID		ENSG00000132664	ENSG00000101004
Uniprot IDs		Q05DB8 Q9H1D9	Q9Y2I6
PDB IDs		2DK5 2YU3
Enriched GO Terms of Interacting Partners?
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