DRAP1 and DR1

Number of citations of the paper that reports this interaction (PubMedID 8670811)
65

Data Source:
HPRD (in vitro, in vivo)

		DRAP1	DR1
Description		DR1 associated protein 1	down-regulator of transcription 1
Image
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Negative Cofactor 2 Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Binding DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Histone H3 Acetylation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by NODAL Signaling by Activin	HATs acetylate histones
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)	Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolic syndrome ( 31589552) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528)
Interacting Genes		26 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX2 NCK2 NFYB PIK3R3 PLEKHF2 POLE3 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	8 interacting genes: DNMT3L DRAP1 NFIL3 POLE3 TBP XPO1 YEATS2 ZDHHC17
Entrez ID		10589	1810
HPRD ID		03796	03284
Ensembl ID		ENSG00000175550	ENSG00000117505
Uniprot IDs		Q14919	Q01658 Q658N3
PDB IDs		1JFI	1JFI
Enriched GO Terms of Interacting Partners?
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