TRIM38 and HSPA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM38	HSPA2
Description		tripartite motif containing 38	heat shock protein family A (Hsp70) member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Tau Protein Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Glycolipid Binding Disordered Domain Specific Binding
	Biological Process	Regulation Of Interferon-beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Protein K48-linked Ubiquitination	Positive Regulation Of Protein Phosphorylation Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Positive Regulation Of ATPase Activity Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Calcium-transporting ATPase Activity
Pathways		Interferon gamma signaling	Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase
Drugs			Quercetin
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cardiac hypertrophy ( 21348951) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		21 interacting genes: ATXN1 EIF1B GMCL1 GORASP2 HSPA1A HSPA2 HSPA8 RFC5 RIPK1 SDCBP STXBP1 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U	9 interacting genes: APP CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38
Entrez ID		10475	3306
HPRD ID		15555	07174
Ensembl ID		ENSG00000112343	ENSG00000126803
Uniprot IDs		A0A024QZY4 O00635	A0A024R6B5 P54652
PDB IDs			3I33 4FSV 5FPD 5FPE 5FPM 5FPN
Enriched GO Terms of Interacting Partners?
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