TRIM38 and UBE2E3

Number of citations of the paper that reports this interaction (PubMedID 21143188)
39

Data Source:
BioGRID (two hybrid)

		TRIM38	UBE2E3
Description		tripartite motif containing 38	ubiquitin conjugating enzyme E2 E3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Interferon-beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Protein K48-linked Ubiquitination	Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Interferon gamma signaling	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cardiac hypertrophy ( 21348951) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Ankylosing spondylitis ( 23749187) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) White blood cell count ( 27863252)
Interacting Genes		21 interacting genes: ATXN1 EIF1B GMCL1 GORASP2 HSPA1A HSPA2 HSPA8 RFC5 RIPK1 SDCBP STXBP1 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U	84 interacting genes: ACVR1 ARID3A ARIH2 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WWP2 ZNF746 ZNRF1 ZNRF4
Entrez ID		10475	10477
HPRD ID		15555	05000
Ensembl ID		ENSG00000112343	ENSG00000170035
Uniprot IDs		A0A024QZY4 O00635	Q969T4 R4GNG6
PDB IDs
Enriched GO Terms of Interacting Partners?
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