PIBF1 and MAP3K2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		PIBF1	MAP3K2
Description		progesterone immunomodulatory binding factor 1	mitogen-activated protein kinase kinase kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Nucleus Cytoplasm Centrosome Centriolar Satellite	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Interleukin-4 Receptor Binding Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Immune System Process Mitotic Metaphase Plate Congression Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Cilium Assembly Protein Localization To Centrosome Mitotic Spindle Assembly Non-motile Cilium Assembly	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus
Pathways
Drugs			Bosutinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood pressure measurement (low sodium intervention) ( 24165912) Mean corpuscular hemoglobin ( 27863252) Waist circumference ( 28552196)	Protein C levels ( 28082259)
Interacting Genes		5 interacting genes: APP CEP135 CEP70 HAUS1 MAP3K2	25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ
Entrez ID		10464	10746
HPRD ID		06337	10068
Ensembl ID		ENSG00000083535	ENSG00000169967
Uniprot IDs		Q8WXW3	A0A024RAH0 Q9Y2U5
PDB IDs			2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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