ARIH2 and SLC1A6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARIH2	SLC1A6
Description		ariadne RBR E3 ubiquitin protein ligase 2	solute carrier family 1 member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Intermediate Filament Cytoskeleton Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	High-affinity Glutamate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Neurotransmitter Uptake Ion Transport Chemical Synaptic Transmission Glutamate Secretion Aspartate Transmembrane Transport L-glutamate Transmembrane Transport Regulation Of Membrane Potential L-aspartate Transmembrane Transport L-glutamate Import Across Plasma Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides
Drugs			Glutamic Acid
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		45 interacting genes: ARAP1 BUB1 CBR3 CCDC33 CEP126 DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 NEDD8 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91	2 interacting genes: ARHGEF11 ARIH2
Entrez ID		10425	6511
HPRD ID		09286	09005
Ensembl ID		ENSG00000177479	ENSG00000105143
Uniprot IDs		O95376 Q53ET9 Q6IBL8	B7Z7Q5 P48664
PDB IDs
Enriched GO Terms of Interacting Partners?
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