SLC1A6 and ARHGEF11

Number of citations of the paper that reports this interaction (PubMedID 11242047)
61

Data Source:
HPRD (in vivo, in vitro)

		SLC1A6	ARHGEF11
Description		solute carrier family 1 member 6	Rho guanine nucleotide exchange factor 11
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Intermediate Filament Cytoskeleton Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Cytoplasm Cytosol Membrane
	Molecular Function	High-affinity Glutamate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Metal Ion Binding	G Protein-coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Neurotransmitter Uptake Ion Transport Chemical Synaptic Transmission Glutamate Secretion Aspartate Transmembrane Transport L-glutamate Transmembrane Transport Regulation Of Membrane Potential L-aspartate Transmembrane Transport L-glutamate Import Across Plasma Membrane	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
Drugs		Glutamic Acid
Diseases
GWAS		Familial squamous cell lung carcinoma ( 29924316)	Chin dimples ( 27182965) Heel bone mineral density ( 30598549) Height ( 31562340)
Interacting Genes		2 interacting genes: ARHGEF11 ARIH2	15 interacting genes: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6
Entrez ID		6511	9826
HPRD ID		09005	09302
Ensembl ID		ENSG00000105143	ENSG00000132694
Uniprot IDs		B7Z7Q5 P48664	O15085
PDB IDs			1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?
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