ARIH2 and KCNQ2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARIH2	KCNQ2
Description		ariadne RBR E3 ubiquitin protein ligase 2	potassium voltage-gated channel subfamily Q member 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Node Of Ranvier Axon Initial Segment Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Ankyrin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Chemical Synaptic Transmission Nervous System Development Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Voltage gated Potassium channels Interaction between L1 and Ankyrins
Drugs			Amitriptyline Diclofenac Meclofenamic acid Ezogabine ICA-105665
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Perceived intensity of neohesperidin dihydrochalcone ( 31005972)
Interacting Genes		45 interacting genes: ARAP1 BUB1 CBR3 CCDC33 CEP126 DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 NEDD8 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91	6 interacting genes: ARIH2 CALM1 CALM2 CALM3 KCNQ3 PRKCA
Entrez ID		10425	3785
HPRD ID		09286	03757
Ensembl ID		ENSG00000177479	ENSG00000075043
Uniprot IDs		O95376 Q53ET9 Q6IBL8	O43526 Q53Y30
PDB IDs			5J03 6FEG 6FEH
Enriched GO Terms of Interacting Partners?
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